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KMID : 1143220230660030169
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Obstetrics & Gynecology Science
2023 Volume.66 No. 3 p.169 ~ p.180
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The introduction to air pollution on pregnancy outcome (APPO) study: a multicenter cohort study
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Hur Young-Min
Park Sun-Wha
Kwon Eun-Jin
You Young-Ah
AbuZar Ansari
Kim Soo-Min
Lee Ga-In
Park Mi-Hye
Lee Kyung-A
Kim Soo-Jung
Kim Young-Han
Jung Yeon-Sung
Cho Geum-Joon
Oh Min-Jeong
Na Sung-Hun
Lee Se-Jin
An Tae-Gyu
Bae Jin-Gon
Kim Yu-Hwan
Lee Soo-Jeong
Kim Na-Kyung
Ha Eun-Hee
Kim Young-Ju
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Abstract
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ObjectiveThe air pollution on pregnancy outcome (APPO) study is a prospective hospital-based cohort study designed to investigate the maternal and fetal effects of a particulate matter with an aerodynamic below 10 μm (PM10) and PM2.5 (below 2.5 μm) exposure. This study aims to analyze a relationship between particulate matter and adverse pregnancy outcomes and to find related biomarkers and develop management guidelines.
MethodsAbout 1,200 pregnant women are recruited for 3 years (from January 2021 to December 2023) from seven university hospitals to investigate the effects of particulate matter on pregnancy complications and adverse pregnancy outcomes. We collect biological samples by 5 mL of maternal venous blood and 15 mL of urine in each trimester of pregnancy, and 5 mL of umbilical cord blood and 2×2×2 cm of placental tissue are collected after delivery. In addition, by applying PM10 and PM2.5 concentration values and time-activity patterns from the time weighted average model, the individual predicted exposure of air pollution for the pregnant women are obtained.
ResultsThe average exposure of PM10 and PM2.5 of the participants in the entire period of pregnancy, was exceeded the World Health Organization air quality guidelines (an annual level, PM10 >15 μg/m3, PM2.5 >5 μg/m3). Moreover, it was revealed that the PM concentration was increasing toward the 3rd trimester of pregnancy.
ConclusionThe APPO study will be able to identify the degree of exposure to air pollution in pregnant women and use it as basic data for estimating individual exposure to particulate matter. And the results of the APPO study will facilitate in the development of health management for pregnant women against air pollution.
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KEYWORD
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Particulate matter, Air pollution, Environmental exposure, Pregnant women, Pregnancy complications
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FullTexts / Linksout information
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